#825: Dr. Dominic D’Agostino — All Things Ketones, How to Protect the Brain and Boost Cognition, Sardine Fasting, Diet Rules, Revisiting Metformin and Melatonin, and More

Tim Ferriss hosts Dr. Dominic D'Agostino, a prominent researcher and expert on ketosis. They dive into various aspects of ketosis, detailing the differences between types of supplemental ketones, their effects on health, and practical usage tips for those interested in the ketogenic diet. Ferriss shares personal experiences with ketones, discussing the importance of combining them with medium-chain triglycerides (MCTs) for effectiveness. Dr. D'Agostino highlights the role of ketones in addressing neurodegenerative conditions like Alzheimer's disease, exploring their potential to provide alternative energy sources to the brain when glucose metabolism is impaired.

They also cover concerns regarding the safety of long-term ketone supplementation, especially regarding liver toxicity associated with certain types of ketone esters. Additionally, they discuss the significance of maintaining an appropriate range of ketone levels in the blood to avoid adverse side effects, particularly anxiety.

The conversation then shifts to broader applications for ketones, including their emerging role in metabolic psychiatry and cancer therapy. D'Agostino presents exciting findings from his research regarding ketones' anxiolytic effects and potential benefits for psychiatric conditions. They acknowledge how ketones could support traditional treatments while enhancing immune function in cancer therapies.

Finally, D'Agostino shares insights on hyperbaric oxygen therapy and its potential benefits when combined with ketones, leading to a compelling discussion about the future of metabolic therapies in various health contexts. Throughout the episode, listeners are encouraged to consider the nuances of their health strategies and remain informed about ongoing research in the field.